Circadian secretion pattern of copeptin, the C-terminal vasopressin precursor fragment.
نویسندگان
چکیده
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منابع مشابه
Copeptin,as a new Boimarker
everything that disturbs the homeostatic balance of the body can be defined as stress and any stress factor activating the hypothalamic- pituitary-adrenal (HPA) axis causes an increase in arginine vasopressin (AVP) plasma concentrations. AVP is a 9 amino acid peptide in the ring structure and derived from pre-pro vasopressin. Pre-pro vasopressin is a pro hormone that synthesized by supraoptic ...
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Copeptin, a precursor of vasopressin is released when the hypothalamic-pituitary-adrenal axis (HPA) is activated in response to stress. Copeptin secretion from the posterior pituitary gland is in equimolar amounts with arginine vasopressin, hence it reflects arginine vasopressin concentration and can be used as surrogate biomarker of arginine vasopressin secretion. Measurement of copeptin level...
متن کاملThe Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin
BACKGROUND Several studies have investigated copeptin as a prognostic marker of different acute diseases and as a diagnostic marker in disorders of water and salt homeostasis. However, no data of the normal circadian rhythm of copeptin in healthy subjects are available. AIM To investigate the circadian rhythm of copeptin in healthy subjects under standardized conditions. METHODS 19 healthy ...
متن کاملCopeptin and its potential role in diagnosis and prognosis of various diseases
The need for faster diagnosis, more accurate prognostic assessment and treatment decisions in various diseases has lead to the investigations of new biomarkers. The hope is that this new biomarkers will enable early decision making in clinical practice. Arginine vasopressin (AVP) is one of the main hormones of the hypothalamic-pituitary-adrenal axis. Its main stimulus for secretion is hyperosmo...
متن کاملCopeptin under glucagon stimulation
Stimulation of growth hormone (GH) and adrenocorticotropic hormone (ACTH) secretion by glucagon is a standard procedure to assess pituitary dysfunction but the pathomechanism of glucagon action remains unclear. As arginine vasopressin (AVP) may act on the release of both, GH and ACTH, we tested here the role of AVP in GST by measuring a stable precursor fragment, copeptin, which is stoichiometr...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 56 7 شماره
صفحات -
تاریخ انتشار 2010